26/03/2026
Never mix Ceftriaxone with Ringer’s lactate. The calcium in Ringer’s lactate reacts with ceftriaxone to form dangerous precipitates (crystals), which can block IV lines and harm organs like kidneys, lungs etc.
Safe ways to administer:
1- Use separate IV lines is the Best option
a- Give ceftriaxone through one IV line
b- Give Ringer’s lactate through another IV line
2- Stop Ringer’s lactate, flush line with normal saline (0.9% NaCl) thoroughly and give ceftriaxone flush again with normal saline and restart Ringer’s lactate.
NOTE
This completely avoids mixing. And someone like me may think since all the infusions are through IV they can still meet in the bloodstream, However this considered safe.✅